Author Affiliations: UnitedHealth Chronic Disease Initiative, London, United Kingdom (Dr Smith); and Population Health Research Institute, McMaster University and Hamilton Health Sciences, Hamilton, Ontario, Canada (Drs McCready and Yusuf).
Cardiovascular disease is the major cause of mortality and morbidity globally and affects half of all individuals over their lifetimes.1 The burden of cardiovascular disease in developing countries is increasing substantially, and cardiovascular disease is becoming the leading cause of death.1 The concept of combining antihypertensive drugs, a statin, and aspirin into a single, fixed-dose, combination pill to prevent myocardial infarction and stroke is now a dozen years old, but still no such pill is licensed in most countries.
Smith R, McCready T, Yusuf S. Combination Therapy to Prevent Cardiovascular DiseaseSlow Progress. JAMA. 2013;309(15):1595-1596. doi:10.1001/jama.2013.3180