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March 27, 2013

Aspirin Use and Risk of Macular Degeneration—Reply

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliations: Department of Ophthalmology and Visual Sciences, University of Wisconsin School of Medicine and Public Health, Madison (kleinb@epi.ophth.wisc.edu).

JAMA. 2013;309(12):1227-1228. doi:10.1001/jama.2013.2041

In Reply: Dr Nowroozzadeh noted that the examination question used to identify regular aspirin users was inappropriate because persons regularly using aspirin may consume it more than twice per week over the previous 3 months. The question is aimed to identify self-reported regularity of use, not necessarily one's cumulative aspirin consumption over a 3-month period. We agree, based on more detailed dosing information collected at later visits, that persons reporting regular aspirin use do tend to use aspirin more than twice per week, especially those using aspirin for cardioprophylaxis or arthritis. Persons who do not use aspirin at least this frequently are not regular aspirin users and therefore would not be incorrectly classified using our definition.

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