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January 11, 2012

Supplementation in Acute Lung Injury

Author Affiliations

Author Affiliations: Department of Anesthesiology, Critical Care and Pain Medicine, Neuperlach Medical Center, Munich, Germany (Dr Felbinger); Departments of Anesthesiology, Critical Care and Pain Medicine (Dr Weigand) and Internal Medicine (Dr Mayer) (, University Hospital of Giessen and Marburg, Giessen, Germany.

JAMA. 2012;307(2):144-146. doi:10.1001/jama.2011.1982

To the Editor: Dr Rice and colleagues1 provided evidence that twice-daily enteral supplementation of omega-3 (n-3) fatty acids, γ-linolenic acid (GLA), and antioxidants changed plasma levels of n-3 fatty acids but did not improve clinical outcomes or biomarkers of systemic inflammation in patients with acute lung injury (ALI). These results are in contrast to older studies in patients with ALI or adult respiratory distress syndrome and another recent multicenter trial2 in patients with sepsis that demonstrated positive effects of n-3 fatty acids, GLA, and antioxidants.