Altered expression of a small noncoding RNA molecule called microRNA-34a in the heart during aging contributes to age-dependent decline in cardiac function, report scientists from Goethe University Frankfurt, in Germany (Boon RA et al. Nature. doi: 10.1038/nature11919 [published online February 20, 2013]).
The researchers found that the hearts of older mice are enlarged and have increased scarring and cell death compared with the hearts of younger mice. Analyses of the expression of microRNAs isolated from the hearts of these mice identified a number of dysregulated microRNAs.
Hampton T. Age-Dependent Heart Damage. JAMA. 2013;309(13):1337. doi:10.1001/jama.2013.3157