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April 10, 2013

Birt-Hogg-Dubé Syndrome

Author Affiliations

Author Affiliations: Myrovlytis Trust, London, England (

JAMA. 2013;309(14):1460-1461. doi:10.1001/jama.2013.2243

To the Editor: In the Clinical Challenge describing a patient with Birt-Hogg-Dubé syndrome, Felton and Madan1 stated that “The most important work-up to perform in suspected or confirmed cases of Birt-Hogg-Dubé syndrome is a renal tract ultrasound. . . . ” Although ultrasound will detect lesions larger than 25 mm with 100% accuracy, ultrasound is unable to detect smaller masses as reliably.

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