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April 17, 2013

Vitamin D Supplementation in Patients With Osteoarthritis

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliations: Menzies Research Institute Tasmania, University of Tasmania, Hobart, Australia (

JAMA. 2013;309(15):1583-1584. doi:10.1001/jama.2013.3775

To the Editor: Dr McAlindon and colleagues1 reported that vitamin D supplementation for 2 years at a dose sufficient to elevate 25-hydroxyvitamin D plasma levels to higher than 36 ng/mL did not reduce knee pain or cartilage volume loss in patients with symptomatic knee osteoarthritis. However, this study has several potential limitations that might make the conclusions problematic.

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