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May 1, 2013

Differential Effects of Fructose and Glucose on Cerebral Blood Flow

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliation: Chifley, New South Wales, Australia (

JAMA. 2013;309(17):1768. doi:10.1001/jama.2013.3364

To the Editor: Even though the changes in brain activity and cerebral blood flow after ingestion of fructose and glucose are interesting, additional information on actual physical manifestations of those changes is required to make recommendations, as noted by Dr Page and colleagues.1

They stated that “There was no significant difference between glucose vs fructose ingestion on predrink-postdrink changes in hunger (mean difference, 0.7 [95% CI, −0.4 to 1.7]; P = .22), fullness (mean difference, −0.9 [95% CI, −2.1 to 0.2]; P = .09), or satiety (mean difference, −1.0 [95% CI, −2.3 to 0.4]; P = .15).” However, they reported a significant predrink to postdrink difference in fullness and satiety with glucose but not fructose.

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