A novel research technique named CLARITY that renders brain tissue transparent while preserving the integrity of the organ is creating a stir in the field of neuroscience—and beyond. By allowing scientists to examine intact neural connections in the brain postmortem, the approach is expected to help them gain a deeper understanding of the brain.
CLARITY was developed by a team of investigators led by Karl Deisseroth, MD, PhD, professor of bioengineering, psychiatry, and behavioral sciences at Stanford University, Stanford, Calif. Previously, Deisseroth's laboratory came up with optogenetics, a groundbreaking technique that allows researchers to control the activity of neurons in living tissue by exciting them with light.
Friedrich MJ. Technique That Turns Brain Transparent Allows Probing of Intact Neural Circuitry. JAMA. 2013;309(21):2204. doi:10.1001/jama.2013.4961