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June 26, 2013

Fibrosis and Mortality in Patients With Dilated Cardiomyopathy—Reply

Author Affiliations

Letters Section Editor: Jody W. Zylke, MD, Senior Editor.

Author Affiliations: Royal Brompton Hospital, London, England (s.prasad@rbht.nhs.uk).

JAMA. 2013;309(24):2547-2549. doi:10.1001/jama.2013.6467

In Reply: The latest international heart failure guidelines identify more than 50 potential prognostic variables for patients with heart failure.1 However, although these parameters have been shown to provide independent prognostic value, there is no consistency among studies regarding the covariates used in multivariate modeling.

Furthermore, the incremental prognostic value has not been ascertained for most variables. Even though a number of risk prediction models incorporating many of these factors have been proposed, their complexity and varying availability of the constituent variables mean that they are not routinely used in clinical practice.2

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