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September 14, 2011

Urinary Sodium Excretion and Cardiovascular Disease Mortality

Author Affiliations

Author Affiliations: Department of Epidemiology, German Institute of Human Nutrition Potsdam-Rehbrücke, Nuthetal, Germany (Drs Aleksandrova and Weikert) (; and Molecular Epidemiology Group, Max Delbrück Center for Molecular Medicine, Berlin-Buch, Germany (Dr Pischon).

JAMA. 2011;306(10):1083-1087. doi:10.1001/jama.2011.1291

To the Editor: Dr Stolarz-Skzypek and colleagues reported that lower urinary sodium excretion was associated with higher cardiovascular disease (CVD) mortality.1 These findings contradict a large body of evidence that established elevated sodium consumption as a risk factor for CVD and shed doubts on the worldwide efforts to implement population-based sodium reduction strategies.2 We have a number of concerns that suggest their findings should be interpreted cautiously.