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August 24/31, 2005

Surfactant and Pediatric Acute Lung Injury—Reply

JAMA. 2005;294(8):898-899. doi:10.1001/jama.294.8.899-a

In Reply: We agree with Drs Hunt, Schwartz, and Fackler that the statement in the abstract of our article that calfactant “ . . . significantly decreased mortality in infants, children, and adolescents with ALI . . . ”1 should not be construed to imply that mortality was significantly decreased in each age group. Study entry was not stratified by age, and the subgroup analysis of infants was performed post hoc in an attempt to understand if the observed survival difference was limited to this age group.