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Comment and Response
July 24/31, 2013

Sildenafil and Exercise Capacity in Heart Failure

Author Affiliations
  • 1Heart Failure Unit, San Donato University Hospital, Milan, Italy
  • 2Pulmonary Hypertension and Right Heart Failure Program, Temple Heart and Vascular Center, Philadelphia, Pennsylvania
JAMA. 2013;310(4):432. doi:10.1001/jama.2013.7437

To the Editor The Phosphodiesterase-5 Inhibition to Improve Clinical Status and Exercise Capacity in Heart Failure with Preserved Ejection Fraction (RELAX) trial1 found that sildenafil did not improve exercise capacity or clinical status compared with placebo in patients with heart failure with preserved ejection fraction (HFPEF). The population enrolled had a constellation of comorbid diseases and risk factors.

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