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Comment and Response
July NaN, 2013

Chelation Therapy and Cardiovascular Outcomes

Author Affiliations
  • 1Department of Anesthesiology, Edward Hines Jr VA Hospital, Hines, Illinois
JAMA. 2013;310(4):431. doi:10.1001/jama.2013.7930

To The Editor The Trial to Assess Chelation Therapy (TACT) concluded that chelation therapy modestly reduced the risk of adverse cardiac outcomes.1 Dr Nissen, in his Editorial,2 pointed out that despite TACT being a randomized clinical trial (the criterion standard for clinical research), not all randomized clinical trials are equal. Likewise, Browner and Newman3 (almost 30 years ago) pointed out that not all significant P values are equal.

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