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In Reply Dr Bittl references evidence that associates cadmium levels with
atherosclerosis and points out that EDTA is an effective chelator for many xenobiotic heavy metals.
Heavy metals promote oxidant stress and, as such, may be causative in atherosclerosis.1 The heavy metal hypothesis, as mentioned in the Discussion
section of our article, is a possible explanation for the results of TACT.
Lamas GA, Mark D, Lee KL. Chelation Therapy and Cardiovascular Outcomes—In
Reply. JAMA. 2013;310(4):431-432. doi:10.1001/jama.2013.7954