Insight into how an antipsychotic drug used to treat schizophrenia acts on bacteria may pave the way for developing antibiotics to kill drug-resistant bacteria.
Researchers in Denmark examined how thioridazine acted on methicillin-resistant Staphylococcus aureus grown in culture. They found that the drug weakened the bacteria by removing the amino acid glycine, which helps form the scaffold of the bug’s cell wall and allows an antibiotic to attack and kill resistant bacteria. The finding could help launch new ways to treat bacteria that have outwitted many or even all existing antibiotics.
From JAMA’s Daily News Site. JAMA. 2013;310(4):360. doi:10.1001/jama.2013.17301