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May 6, 1983

Factor VIII Concentrate— Hepatitis

Author Affiliations

Tulane University School of Medicine New Orleans

JAMA. 1983;249(17):2331. doi:10.1001/jama.1983.03330410029023

To the Editor.—  Ten years ago, Kasper and Kipnis pointed out the likelihood of hepatitis developing in hemophiliacs (1972;221:510). Their study primarily dealt with clinical symptomatology and evaluated the incidents in patients with hemophilia and frequent blood transfusions as well as those who had never received blood products.1,2 We have had experience with six consecutive patients who had never received factor concentrate and no blood products of any kind for at least five years previously.

Report of Cases.—  We studied the clinical course and serological studies of six patients with factor VIII deficiency (Table). Between them, they received commercial factor VIII concentrates from three different manufacturers. Three patients had only a single dose (1,000 to 1,800 antihemophilic factor units). One patient had von Willebrand's disease and the other five had mild to severe factor VIII deficiency. Treatment was given for surgical needs (four) or hemarthroses (two). Patients 3 and