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June 16, 1993

Blood Pressure and Serum Creatinine

Author Affiliations

National Institute on Aging Bethesda, Md

JAMA. 1993;269(23):2983-2984. doi:10.1001/jama.1993.03500230065018

To the Editor.  —We were intrigued by the report of Perneger et al1 that blood pressure level was associated with subsequent creatinine levels in middle-aged adults and wanted to replicate the analysis using data on older adults. We examined data from 3958 older residents of three communities in the Established Populations for the Epidemiologic Studies of the Elderly,2,3 whose blood pressure was measured (average of two readings) in 1982 and 1983 and in 1988 and 1989 and serum creatinine was analyzed in 1988 and 1989. We performed a statistical analysis similar to that reported by Perneger et al and found somewhat similar results.Serum creatinine level was associated more strongly with past than with current blood pressure levels (Table). Limiting the analysis to participants who were not receiving antihypertensive therapy at the time of their blood pressure measurement in 1982 and 1983 had little effect on the results.