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May 24, 1995

Developmental Care for Very Low-Birth-Weight Infants-Reply

Author Affiliations

Harvard Medical School
Brigham and Women's Hospital Boston, Mass

JAMA. 1995;273(20):1577-1578. doi:10.1001/jama.1995.03520440027023

In Reply.  —We thank those who wrote for their vigorous criticism and feedback, which has provided us with an opportunity to further explore our conclusions.Groups did not differ in severity of initial illness, as reconfirmed by analysis of variance of score for neonatal acute physiology1 (P<.42) and background variable MANOVA (P<.59). All eligible infants meeting the initial 3-hour criteria also met the 48-hour criteria. Only two control group infants were unavailable for study; one died at 8 months, the other moved out of state. Outcome measures were predetermined and directionality was hypothesized, calling for one-tailed tests.2(p14) Only three of the 11 "significant" outcome variables narrowly miss the two-tailed.05 level. Considering that all our infants weighed 1250 g or less and were aged 29 weeks or less, control group IVH incidence of 55.56% compares favorably with other estimates of overall incidence (51.13%3(Table 5)) for infants