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In Reply As is true of all analgesics, duloxetine’s effect in diminishing pain severity due to chemotherapy-induced neuropathy is modest. When averaged over the entire treated population, analgesic effects appear modest because the analgesic will work well in some people but not at all in others.1,2 But to the patients who experience meaningful symptom improvement, these effects are not modest.
Smith EML, Pang H. Therapy for Chemotherapy-Induced Peripheral Neuropathy—In
Reply. JAMA. 2013;310(5):538. doi:10.1001/jama.2013.7905