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From the JAMA Network
August 14, 2013

Zonisamide for Weight Reduction in Obese Adults

Author Affiliations
  • 1Section of Endocrinology, Diabetes and Nutrition, Boston University School of Medicine, Boston, Massachusetts
  • 2Department of Medicine, Weill Cornell Medical College, New York, New York
JAMA. 2013;310(6):637-638. doi:10.1001/jama.2013.101049

Obesity treatments including diet, exercise, and behavior modification, while successful in the short-term, may fail with time in a significant number of patients. Research has shown that only 20% of overweight individuals are successful at long-term weight loss when success is defined as losing at least 10% of initial body weight and maintaining the loss for at least 1 year.1,2

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