To the Editor The primary objective of the systematic review by Dr Lin and
colleagues1 was “to review the clinical efficacy and
safety of sublingual immunotherapy delivered as an aqueous solution as can potentially be done in
the United States.” The authors reported that there are physicians in the United States who
use subcutaneous aqueous allergens off-label for sublingual desensitization. However, the doses
administered by subcutaneous immunotherapy and sublingual immunotherapy are very different.
Frati F, Incorvaia C, Passalacqua G. Efficacy of Sublingual Immunotherapy. JAMA. 2013;310(6):643-644. doi:10.1001/jama.2013.7646