To the Editor In a JAMA Clinical Challenge, Drs Ding and Fang1 discussed a case study of cryptococcosis in a febrile renal transplant recipient. We wish to comment on the choice of itraconazole as therapy for this patient.
Cultures of the skin biopsy and sputum confirmed a diagnosis of disseminated cryptococcosis in this immunocompromised patient who was treated with intravenous itraconazole for the first 2 weeks. She died of meningoencephalitis of unclear etiology a few months later.
Chandrasekar PH, Revankar SG. Cryptococcosis in a Febrile Renal Transplant Recipient. JAMA. 2013;310(7):748. doi:10.1001/jama.2013.124260