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April 23/30, 2003

Long-term Cardiovascular Consequences of Diuretics vs Calcium Channel Blockers vs Angiotensin-Converting Enzyme Inhibitors

JAMA. 2003;289(16):2066. doi:10.1001/jama.289.16.2068-a

To the Editor: The ALLHAT authors1 do not comment on the curious finding that patients who received chlorthalidone were twice as likely as those assigned to amlodipine to die of unintentional injury, suicide, or homicide. Although the absolute difference in the risk (0.3 persons per 6-year per 100 persons) was small, it did reach statistical significance. The difference in the rate between chlorthalidone and lisinopril was in the same direction but did not reach statistical significance.