To the Editor: The ALLHAT authors1 reported
that during a 4-year period, glomerular filtration rate (GFR) was best preserved
in the patients on amlodipine and declined most in those receiving chlorthalidone.
The authors then dismissed this finding by suggesting that the African American
Study of Kidney Disease and Hypertension (AASK) study2 group
had pointed to a detrimental effect of amlodipine on renal function with a
faster rate of decline of GFR.
Long-term Cardiovascular Consequences of Diuretics vs Calcium Channel
Blockers vs Angiotensin-Converting Enzyme Inhibitors. JAMA. 2003;289(16):2066. doi:10.1001/jama.289.16.2068-b