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August 3, 2005

Human Skeletal Muscle as a Target Organ of Trichloroethylene Toxicity

JAMA. 2005;294(5):551-556. doi:10.1001/jama.294.5.554-b

To the Editor: Trichloroethylene (TCE) is widely used as a metal degreaser, dry cleaning solvent, spot remover, adhesive, lubricant, and anesthetic and analgesic agent.1 In humans, it can induce acute toxicity, most commonly in the kidney, liver, and central nervous system.2 Most TCE toxicity depends on bioactivation by either cytochrome P450–dependent oxidation or glutathione conjugation.2 We are not aware of previous reports of human skeletal muscle damage after acute poisoning by TCE.