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Medical News and Perspectives
August 10, 2005

Hormone Changes in Aging Adults Probed

JAMA. 2005;294(6):663-667. doi:10.1001/jama.294.6.663

San Diego—Endocrinologists have known for decades that growth hormone (GH) levels decline with age and that a deficit in this hormone can bring increases in fat mass, declines in lean mass, a greater risk of osteopenia, a decrease in exercise tolerance, and an adverse cardiac risk profile. Interest in GH and its deficiency is now on the rise—and not only for traditional medical uses of GH replacement therapy. In various settings, including the Internet, GH treatments are sometimes being touted as the latest incarnation of the “fountain of youth,” miring them in controversy.