San Diego—With the widespread use of
antiretroviral therapy, the life expectancy of many patients with HIV has
increased substantially in recent years. As opportunistic infections have
become less commonly associated with patient mortality, concerns are increasingly
shifting to the impact of such chronic health conditions as diabetes mellitus
and cardiovascular and liver diseases in this patient population.
In fact, the prevalence of diabetes and insulin resistance has grown
among patients with HIV, and these conditions are “becoming increasingly
recognized as a health problem for our patients,” said Colleen M. Hadigan,
MD, MPH, assistant professor of pediatrics at Harvard Medical School, Boston,
Mass. At a symposium on secondary diabetes at the 65th Scientific Sessions
of the American Diabetes Association here in June, she described the direct
and indirect effects of antiretrovirals as significant contributors to insulin
resistance in the presence of HIV infection.
Researchers Investigate Factors Linked to Development of Secondary
Diabetes. JAMA. 2005;294(6):668-670. doi:10.1001/jama.294.6.668