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December 7, 2005

Operating Characteristics of Prostate-Specific Antigen and Verification Bias—Reply

JAMA. 2005;294(21):2698-2699. doi:10.1001/jama.294.21.2698-b

In Reply: We are pleased that our results, with 65.2% biopsy verification, confirmed the operating characteristics of PSA reported by Dr Punglia and colleagues1 from a study sample with 10.5% verification. While we agree that there is no evidence of violation of the mathematical requirements for applying the Begg and Greenes verification bias adjustment algorithm2 at face value, we do have concerns about this.