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December 21, 2011

Depression and Risk of Stroke

Author Affiliations

Author Affiliations: Division of Epidemiology, Chinese University of Hong Kong, Hong Kong SAR, China (maochen@cuhk.edu.hk).

JAMA. 2011;306(23):2562-2563. doi:10.1001/jama.2011.1841

To the Editor: Dr Pan and colleagues1 examined the association between depression and the risk of stroke morbidity and mortality. We are concerned about the methodological quality of the meta-analysis.

Some of the extracted data were inconsistent with that reported in the original studies. In the study by Larson et al,2 the measure of risk should be relative risk (RR), not odds ratio (OR)1; and the value of RR should be 3.08 (95% CI, 1.26-7.52) (Table 3 and page 1981),2 not 2.67 (95% CI, 1.08-6.63).1 In the study by Stürmer et al,3 the number of stroke cases should be 50, not 62, and the outcome measure should be total stroke, not nonfatal stroke.