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A massive database created by scientists from the National Cancer Institute (NCI) could help researchers understand the genetic underpinnings of cancer and how these might be exploited to improve drug treatment.
In a recent publication, Yves Pommier, MD, PhD, chief of the Laboratory of Molecular Pharmacology at the NCI, and colleagues describe results from the whole-exome sequencing of 60 human cancer cell lines, including cancers of the lung, colon, brain, ovary, breast, prostate, skin, blood, and kidneys. These 60 lines, referred to as the NCI-60, are used extensively by cancer researchers, who will be able to access the data set for more information about the genetics of these lines.
Kuehn BM. Database a Trove of Information on Cancer Genetics, Drug Responses. JAMA. 2013;310(8):787. doi:10.1001/jama.2013.276616