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Patients with diabetes and physicians are aware of the distress and on rare occasions mortality caused by severe hypoglycemia, in particular by nocturnal hypoglycemia. Up to 75% of severe hypoglycemia episodes in children occur at night,1 and concern about hypoglycemia is a major barrier to achieving target glycemic levels, often leading to maladaptive behaviors, such as underdosing insulin or taking extra carbohydrates, that increase blood glucose levels, again most pronounced at night.2
Choudhary P. Insulin Pump Therapy With Automated Insulin SuspensionToward Freedom From Nocturnal Hypoglycemia. JAMA. 2013;310(12):1235-1236. doi:10.1001/jama.2013.278576