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November 13, 2013

From JAMA’s Daily News Site

JAMA. 2013;310(18):1911. doi:10.1001/jama.2013.281101

Health professionals should begin immediate postexposure prophylaxis (PEP) with at least 3 antiretroviral drugs if they’re occupationally exposed to HIV, according to the US Public Health Service.

The updated guideline includes PEP regimens that reflect the availability of newer, better-tolerated antiretroviral agents. The regimen now preferred is a combination of raltegravir and Truvada (tenofovir/emtricitabine). Improved tolerability can help increase the likelihood that health care workers who are being treated will complete the full regimen. Health workers taking PEP should complete a 4-week regimen and undergo follow-up HIV testing, drug toxicity monitoring, and counseling.

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