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Individuals with type 2 diabetes who also have depression had an accelerated cognitive decline during a 40-month cohort study of participants in the Action to Control Cardiovascular Risk in Diabetes–Memory in Diabetes (ACCORD-MIND) trial (Sullivan MD et al. JAMA Psychiatry. 2013;70:1041-1047).
Up to 20% of adult patients with type 2 diabetes have major depression, and both disorders are linked to an increased risk of dementia. The greatest cognitive decline occurred in study participants who had a baseline score of 10 or higher on the Patient Health Questionnaire—18% of the 2977 participants in the ACCORD-MIND substudy. The risk of cognitive decline was not affected by participants’ previous cardiovascular disease, age, intensity of glucose-lowering treatment, blood pressure treatment, or lipid treatment. No participants had dementia at baseline, suggesting that the cognitive decline seen in the study occurred quickly.
Slomski A. Depression Promotes Cognitive Decline in Patients With Diabetes. JAMA. 2013;310(20):2139. doi:10.1001/jama.2013.283537