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Clinical Trials Update
November 27, 2013

Depression Promotes Cognitive Decline in Patients With Diabetes

JAMA. 2013;310(20):2139. doi:10.1001/jama.2013.283537

Individuals with type 2 diabetes who also have depression had an accelerated cognitive decline during a 40-month cohort study of participants in the Action to Control Cardiovascular Risk in Diabetes–Memory in Diabetes (ACCORD-MIND) trial (Sullivan MD et al. JAMA Psychiatry. 2013;70[10]:1041-1047).

Up to 20% of adult patients with type 2 diabetes have major depression, and both disorders are linked to an increased risk of dementia. The greatest cognitive decline occurred in study participants who had a baseline score of 10 or higher on the Patient Health Questionnaire—18% of the 2977 participants in the ACCORD-MIND substudy. The risk of cognitive decline was not affected by participants’ previous cardiovascular disease, age, intensity of glucose-lowering treatment, blood pressure treatment, or lipid treatment. No participants had dementia at baseline, suggesting that the cognitive decline seen in the study occurred quickly.

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