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Clinical Trials Update
November 27, 2013

Statins Reduce Kidney Injury From Contrast Media in At-Risk Patients

JAMA. 2013;310(20):2139. doi:10.1001/jama.2013.283539

Statin therapy should be routinely prescribed to reduce contrast-induced acute kidney injury (CIAKI) in patients with type 2 diabetes or acute coronary syndrome, according to researchers in 2 separate trials.

A multicenter trial in China randomized 2998 patients with type 2 diabetes or mild to moderate chronic kidney disease undergoing coronary/peripheral arterial angiography to either a short course (5 days) of rosuvastatin or to no statins (Han Y et al. J Am Coll Cardiol. doi:10.1016/j.jacc.2013.09.017 [published online October 9, 2013]). Patients receiving rosuvastatin had a 42% relative risk reduction in CIAKI; the incidence of CIAKI in those receiving rosuvastatin was 2.3% compared with 3.9% in the control group. After 30 days, 4.3% of the control group had worsening heart failure vs only 2.6% of patients treated with rosuvastatin.

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