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JAMA Clinical Evidence Synopsis
December 11, 2013

Statin Therapy for Primary Prevention
of Cardiovascular Disease

Author Affiliations
  • 1Department of Noncommunicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, United Kingdom
  • 2Department of Preventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois
  • 3Department of Medicine-Cardiology, Northwestern University Feinberg School of Medicine, Chicago, Illinois
JAMA. 2013;310(22):2451-2452. doi:10.1001/jama.2013.281348
Abstract

Clinical Question  Do statins reduce rates of cardiovascular events when used for primary prevention?

Bottom Line  When used for primary prevention, statins are associated with lower rates of all-cause mortality, major vascular events, and revascularizations compared with placebo. Statin therapy is not associated with increased rates of life-threatening adverse effects such as cancer.

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