[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 319
Citations 0
Lab Reports
December 11, 2013

Compound Protects Against Ionizing Radiation by Unique Mechanism

JAMA. 2013;310(22):2389. doi:10.1001/jama.2013.283993

An investigational cancer preventive agent called 3,3′-diindolylmethane (DIM), which is derived from cruciferous vegetables such as cabbage and broccoli, protects mice against lethal doses of total body irradiation, report researchers from the United States and China (Fan S et al. Proc Natl Acad Sci U S A. doi:10.1073/pnas.1308206110 [published online October 14, 2013]).

DIM dosing initiated before or up to 24 hours after rodents were exposed to 13 Gy of radiation conferred protection. The animals were given once-daily injections of DIM for 2 weeks. Control animals died by day 10, but the 30-day survival rates were 60%, 50%, 20%, and 0% for 75, 45, 15, and 7.5 mg/kg of DIM, respectively.

First Page Preview View Large
First page PDF preview
First page PDF preview