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Lab Reports
December 11, 2013

Compound Protects Against Ionizing Radiation by Unique Mechanism

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Copyright 2013 American Medical Association. All Rights Reserved. Applicable FARS/DFARS Restrictions Apply to Government Use.

JAMA. 2013;310(22):2389. doi:10.1001/jama.2013.283993

An investigational cancer preventive agent called 3,3′-diindolylmethane (DIM), which is derived from cruciferous vegetables such as cabbage and broccoli, protects mice against lethal doses of total body irradiation, report researchers from the United States and China (Fan S et al. Proc Natl Acad Sci U S A. doi:10.1073/pnas.1308206110 [published online October 14, 2013]).

DIM dosing initiated before or up to 24 hours after rodents were exposed to 13 Gy of radiation conferred protection. The animals were given once-daily injections of DIM for 2 weeks. Control animals died by day 10, but the 30-day survival rates were 60%, 50%, 20%, and 0% for 75, 45, 15, and 7.5 mg/kg of DIM, respectively.

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