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Health Agencies Update
December 25, 2013

Certain Gene Variants Associated with Kidney Disease Progression

JAMA. 2013;310(24):2606. doi:10.1001/jama.2013.285000

Individuals with chronic kidney disease who also have certain gene variants are more likely to develop kidney failure than those without these variants, according to an analysis of 2 studies funded by the National Institute of Diabetes and Digestive and Kidney Diseases (Parsa A et al. N Engl J Med. doi:10.1056/NEJMoa1310345 [published online November 9, 2013]).

Variants of the APOL1 gene, which encodes apolipoprotein L1, are also associated with faster progression of kidney disease. These gene variants occur more frequently in black populations, and the risks associated with these gene variants appear greater among black patients.

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