JAMA Clinical Evidence Synopsis
January 1, 2014

Glucocorticoids for Acute Viral Bronchiolitis
in Infants and Young Children

Author Affiliations
  • 1Department of Pediatrics, Santa Maria Hospital, Lisbon Academic Medical Centre, Portugal
  • 2Clinical Pharmacology Unit, Instituto de Medicina Molecular, University of Lisbon, Portugal
  • 3Department of Pediatrics, Alberta Research Centre for Health Evidence, University of Alberta, Edmonton, Canada

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JAMA. 2014;311(1):87-88. doi:10.1001/jama.2013.284921

Clinical Question  Are glucocorticoids, alone or combined with bronchodilators, associated with reduced admission rates, length of stay, or improvements in clinical severity scores without increased adverse effects in infants and young children with acute viral bronchiolitis?

Bottom Line  There is no consistent clinically relevant association of single therapy with systemic or inhaled glucocorticoids and improved outcomes in either outpatient or inpatient settings. Exploratory evidence suggests that combined glucocorticoids and nebulized epinephrine may be associated with lower hospitalization rates in outpatients, but these findings must be interpreted cautiously.