Immune cells in humans and mice under stress demonstrate increased expression of genes that activate inflammation and decreased expression of genes that suppress inflammation, reports a team led by researchers at the Ohio State University, in Columbus, and the University of California, Los Angeles (Powell ND et al. Proc Natl Acad Sci U S A. 2013;110:16574-16579). The investigators’ analysis included individuals who were subject to chronic social stress due to low socioeconomic status and mice that were subject to repeated social defeat.
Hampton T. Stress Affects Expression of Inflammatory Genes in Immune Cells. JAMA. 2014;311(1):19. doi:10.1001/jama.2013.285447