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Comment & Response
January 1, 2014

Combination Pill for Cardiovascular Disease

Author Affiliations
  • 1Department of Diabetes and Metabolic Medicine, National Center for Global Health and Medicine, Tokyo, Japan
JAMA. 2014;311(1):92-93. doi:10.1001/jama.2013.283130

To the Editor The Use of a Multi-drug Pill in Reducing Cardiovascular Events (UMPIRE) trial1 assessed the effects of long-term use of a fixed-dose combination (FDC) containing antiplatelet, statin, and antihypertensive drugs compared with usual care in patients with or at high risk of cardiovascular disease. Although this study yielded many important findings on FDC use, the results should be interpreted carefully.

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