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news@JAMA
January 8, 2014

From JAMA’s Daily News Site

JAMA. 2014;311(2):126. doi:10.1001/jama.2013.285357

Swallowing pills containing concentrated fecal bacteria may be highly effective in preventing recurrent Clostridium difficile infection and related diarrhea, according to recent findings.

The work builds on previous research showing that transplanting feces from healthy donors via enema, colonoscopy, or nasogastric tube successfully treats the infection. Study patients ingested between 24 and 34 capsules containing fecal bacteria. Even though all 32 patients previously had at least 4 bouts of infection, researchers reported a nearly 100% success rate. Only 1 patient had a recurrence of C difficile infection. The case was mild and occurred in the setting of repeated antibiotic use.

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