New research reveals insights into molecular mechanisms that explain why the liver fails to respond appropriately to rising insulin levels in patients with type 2 diabetes (Dentin R et al. Science. 2008;319:1402-1405).
Scientists discovered that chronically elevated blood glucose levels disable the switch that normally shuts off sugar production in the liver. The findings suggest that inhibitors targeting the enzymatic pathway that blocks this switch might help lower glucose levels in patients with diabetes and thereby diminish complications of the disease.
Hampton T. Scientists Find Clues to Glucose Intolerance. JAMA. 2008;299(14):1654. doi:10.1001/jama.299.14.1654