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Letters
February 6, 2008

Trends in the Use of Percutaneous Closure of Patent Foramen Ovale and Atrial Septal Defect in Adults, 1998-2004

JAMA. 2008;299(5):521-522. doi:10.1001/jama.299.5.521

To the Editor: Percutaneous closure of patent foramen ovale/atrial septal defect (PFO/ASD) is perceived as having minimal risk and has been proposed for a broad array of indications.1 The widespread application of this procedure, especially PFO closure, is controversial because of limited data on its efficacy and safety in many settings, including prevention of recurrent cryptogenic stroke.2 We studied trends in the prevalence of PFO/ASD closure in the United States.

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