In Reply We concur with Dr O’Sullivan and Ms Brown that only those trials that use actual clinical outcomes should inform practice. For the great majority of trials that we cited, the common end point was inclusive of myocardial infarction, stroke, revascularization for unstable angina, or vascular death. How one chooses to weight those outcomes is a matter of opinion, and thus we differ somewhat from O’Sullivan and Brown in that we believe a reduction in the need for angioplasty or bypass surgery is a relevant benefit for patients.
Ridker PM, Wilson PWF. Formulation of Treatment Recommendations for Statins—Reply. JAMA. 2014;311(3):306. doi:10.1001/jama.2013.284481