[Skip to Content]
Access to paid content on this site is currently suspended due to excessive activity being detected from your IP address 54.146.141.60. Please contact the publisher to request reinstatement.
[Skip to Content Landing]
Views 260
Citations 0
Global Health
January 15, 2014

Reduced Dose of Primaquine Effective in Blocking Malaria Transmission

JAMA. 2014;311(3):235. doi:10.1001/jama.2013.285742

A single lower dose of primaquine is as effective as the higher standard dose that is recommended for preventing transmission of the malarial parasite Plasmodium falciparum from humans to mosquitoes, report researchers from the London School of Hygiene and Tropical Medicine, in the United Kingdom (Eziefula AC et. Lancet Infect Dis. doi:10.1016/S1473-3099[13]70268-8 [published online November 12, 2013]).

Mature P falciparum gametocytes can persist in the bloodstream after artemisinin combination therapy (ACT). Because of this, primaquine, the only drug that can completely eradicate these gametocytes, has been recommended by the World Health Organization to be used in addition to ACT in many countries.

First Page Preview View Large
First page PDF preview
First page PDF preview
×