Common minor leg injuries such as ankle sprains and muscle ruptures appear to be associated with a higher risk for blood clots in the legs or lungs, according to a large population-based, case-control study by Dutch researchers (van Stralen KJ. Arch Intern Med. 2008;168:21-26).
The study involved 2471 patients who developed venous thrombosis between 1999 and 2004 and 3534 matched controls. About 11.7% of the patients had a minor injury that did not require surgery, a plaster cast, or extended bed rest in the 3 months preceding the venous thrombosis,
compared with 4.4% of the controls. Injuries in the leg were associated with thrombosis while those in other locations were not.
Stephenson J. Thrombosis Risk. JAMA. 2008;299(7):755. doi:10.1001/jama.299.7.755-c