In Reply: Dr Oxnard poses an interesting question concerning our study. The general issue of posttherapy evaluation of treatment response and its timing are applicable to all tumor types.
Clinically, the reference standard of complete treatment response for solid tumors is a pathologically negative tumor biopsy. Positive tumor biopsies, serum tumor markers, and imaging studies may indicate the presence of disease. However, even if 1 of these studies is positive in the immediate posttherapy period, it is not always indicative of ultimate clinical disease progression.
Schwarz JK, Siegel BA, Dehdashti F, Grigsby PW. False-Positive Rate of Posttherapy Positron Emission Tomography in Cervical Cancer—Reply. JAMA. 2008;299(8):898. doi:10.1001/jama.299.8.898-b