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March 5, 2008

Cardiorespiratory Fitness, Adiposity, and Mortality

JAMA. 2008;299(9):1013-1014. doi:10.1001/jama.299.9.1013-b

To the Editor: In the study of cardiorespiratory fitness and adiposity by Dr Sui and colleagues,1 a cohort of 2603 adults older than 60 years was followed up for a mean of 12 years. The authors evaluated the predictive association of measures of adiposity and fat distribution as well as cardiorespiratory fitness with mortality. Fitness and body mass index predicted mortality independently of several established risk factors. Most notably, the effect of fitness was independent of total and abdominal adiposity. To explain this relationship, the authors hypothesize that high fitness levels indicate improved skeletal muscle function, such as strength, power, and endurance.

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