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Book and Media Reviews
March 19, 2008

Gene Therapy for Cancer

JAMA. 2008;299(11):1367-1368. doi:10.1001/jama.299.11.1367-b

Cancer gene therapy is an exciting field that has made great scientific advances, particularly in the last few years. Many clinical trials have been conducted around the world.1 The 2 adenoviral-based drugs—a nonreplicating adenovirus expressing wild type 53 and a replicating 55-kd deleted adenovirus—were recently approved for therapy in China for certain types of cancers. Based on the number of phase 1, 2, and 3 clinical trials currently being conducted in the United States and in other countries, there is no doubt that in the near future there will be many gene therapy–based drugs that will be safe and effective for the treatment of various cancers. The editors of Gene Therapy for Cancer have put together a series of 25 chapters addressing the field of cancer gene therapy research. The book is divided into 3 sections. The first section has 9 chapters and reviews various vectors, the vehicles for DNA delivery. The second section has 10 chapters and describes various current approaches to cancer gene therapy. The final section has 6 chapters and focuses on the clinical applications of cancer gene therapy trials.

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