The creation of 2 artificial DNA building blocks gives researchers the capability of increasing DNA's information potential and may make it possible to synthesize proteins with novel properties (Leconte AM et al. J Am Chem Soc. 2008;130:2336-2343).
Like DNA's natural base-pair constituents, guanine pairing with cytosine and adenine with thymine, the additional DNA nucleotides pair up and could allow researchers to create unique DNA molecules with tailor-made binding or enzymatic activities for use in the laboratory and the clinic, said principal investigator and chemist Floyd Romesberg, PhD, of Scripps Research Institute in La Jolla, Calif.
Hampton T. Researchers Create Artificial DNA Bases. JAMA. 2008;299(11):1251. doi:10.1001/jama.299.11.1251